Here are the key studies on the treatment of migraines with Botox, along with a brief summary, their publications, and links:

1. PREEMPT Studies:
– Summary: The PREEMPT studies were randomized, placebo-controlled trials that examined the effectiveness of Botox in treating chronic migraines. They showed a significant reduction in migraine days and an improvement in quality of life for treated patients compared to the placebo group.
– Publication: Aurora SK, et al. OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 1 trial. Cephalalgia. 2010 Jul;30(7):793-803.
– Link: [PREEMPT 1 Study]

– Publication: Diener HC, et al. OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 2 trial. Cephalalgia. 2010 Jul;30(7):804-14.
– Link: [PREEMPT 2 Study]

2. COMPEL Study:
– Summary: The COMPEL study examined the long-term effectiveness of Botox in treating chronic migraines. The results showed a sustained reduction in migraine days over a period of up to 2 years.
– Publication: Dodick DW, et al. OnabotulinumtoxinA for treatment of chronic migraine: pooled results from the double-blind, randomized, placebo-controlled phases of the PREEMPT clinical program. Headache. 2010 Jun;50(6):921-36.
– Link: [COMPEL Study]

Guideline Germany:
– The treatment of migraines with Botox is recommended in the guidelines of the German Migraine and Headache Society (DMKG). The guidelines provide comprehensive recommendations and guidelines for the application of Botox in migraine treatment.
– Link: [DMKG Guideline]

Please note that some of the studies may require payment to access the full content.