Bio-Remodelling Hyaluronic Acid

Individual cost plan after consultation

Bio-Remodelling — stabilized hyaluronic acid with a dual mechanism of action: deep hydration and active bio-stimulation of fibroblasts. Improves skin quality, tone, and elasticity — not volume. Duration of effect 6–9 months. Standard protocol: 2 sessions 30 days apart. Classic indications: neck, cheeks, hands, décolletage.

Bioregeneration · Skin Quality

When the skin has become thinner

Stabilized hyaluronic acid is introduced at a few defined points and distributes through the tissue. This is about elasticity and moisture, not shape.

Duration of effect6–9 monthsAfter two sessions four weeks apart.

Treatment time15–20 minFew injection points, short treatment.

Onset of effect4–6 weeksThe effect builds up after the second session.

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Short answer: Stabilized hyaluronic acid is injected at a few bolus points and works through water binding plus fibroblast stimulation, not through volume build-up. A randomized, controlled multicenter study in 146 people with three applications to the face, neck, and décolletage documented a significant reduction in superficial fine lines and improved skin radiance through day 120 versus control (Fanian et al. 2023).

Premium Material · Bio-Remodelling

What Bio-Remodelling is as a material class

Bio-Remodelling hyaluronic acid is a distinct class of stabilized hyaluronic acid with a dual mechanism of action: deep hydration of the skin and active bio-stimulation of fibroblasts. Unlike classic hyaluronic acid fillers — which primarily add volume — Bio-Remodelling HA works on skin quality: elasticity, tone, hydration, and structural firmness improve.

The material is injected in a very fluid form, distributes through the tissue, and stimulates the skin's own production of type I and III collagen as well as elastin. A placebo-controlled split-face study with a comparable non-cross-linked hyaluronic acid documented, after a session series, a 35% increase in skin hydration and a 27% increase in skin firmness compared with the untreated control side (Duteil et al. 2023). Duration of effect is typically 6–9 months, often applied in a 2-session protocol (day 0 + day 30). Ideal for patients with early skin laxity who want skin-quality improvement rather than volume.

Mechanism of Action · Dual Effect

How Bio-Remodelling HA works

Mechanism	Effect
Immediate hydration	Highly concentrated HA immediately binds water in the tissue — skin surface appears plumper and fresher within days
Fibroblast stimulation	The stabilized HA activates dermal fibroblasts — an in vitro study on fibroblasts showed increased gene activity for type I and type III collagen as well as elastin after HA bio-revitalization (Palmieri et al. 2017)
Tissue diffusion	Very fluid consistency allows broad distribution across several centimeters — unlike classic fillers, which stay localized
Tissue-quality improvement	Elasticity, hydration, tone, and fine wrinkle depth improve cumulatively over 4–8 weeks after the 2nd session

Bio-Remodelling is not a filler in the classic sense. The material is not injected as a "cushion," but distributed subdermally as an "active ingredient." Anyone seeking volume is better served by a classic hyaluronic acid filler or the hybrid biostimulator — anyone wanting to improve skin quality is in the right place here.

Differentiation

Bio-Remodelling within the material quartet

A skin-quality material — a different indication class

Bio-Remodelling HA belongs to the family of bio-regenerators, but with a distinctly different effect profile than CaHA or PLLA:

Bio-Remodelling HA — skin quality, hydration, gentle bio-stimulation. Duration of effect 6–9 months. 2-session protocol.
PLLA — broad bio-regeneration, structural restoration. Duration of effect 24+ months. 2–3 sessions.
CaHA — immediate volume plus collagen stimulation at structural anchors. Duration of effect 18–24 months. One session.
Hybrid biostimulator (HA+CaHA) — immediate volume plus bio-stimulation combined.

The medical choice of material follows the indication: targeted volume versus broad bio-stimulation versus skin-quality improvement. Bio-Remodelling is the choice for the latter.

Indications · Where Bio-Remodelling fits

Main areas of application

Treatment area	Recommendation
Neck (classic indication)	Standard area — structural improvement of neck skin with early laxity
Cheeks (tissue quality)	Skin-quality improvement without adding volume — ideal before or between classic filler treatments
Hands (skin tone)	Very good indication for the back of the hands with thinning skin
Décolletage	Classic indication — Bio-Remodelling for early horizontal lines on the décolletage
Early skin laxity in general	For patients from age 40 with the first signs of tone loss — preventive/maintaining
Before classic filler treatment	"Tissue conditioning" — improving skin quality before volume fillers are used

Not suitable for: pronounced volume loss (classic fillers more appropriate), deep static wrinkles (hyaluronic acid filler or CaHA more appropriate), a desire for immediate effect (effect builds over 4–8 weeks).

Treatment process · 30 minutes

How your appointment proceeds

Step 1

Assessment and consultation

Evaluation of skin quality — tone, elasticity, hydration status. Explanation of the 2-session protocol and the gradual build-up of effect.

Step 2

Standardized injection

Typically 5 bolus points per area at defined anatomical positions (BAP technique). Very fine needle, no or minimal anesthesia needed.

Step 3

Follow-up session after 30 days

Standard protocol: 2 sessions about 30 days apart. Final result stabilizes 4–8 weeks after the 2nd session.

Distinctions

What Bio-Remodelling is not

Four precise distinctions

Not a classic filler. Bio-Remodelling does not add targeted volume. Anyone wanting "more lip," "more cheek," or a defined chin needs a classic filler.
No immediate effect as with a classic filler. Effect builds over 4–8 weeks — mainly after the 2nd session.
Not a substitute for plastic-surgical lifting. With pronounced skin laxity, a surgical procedure is anatomically more appropriate.
Not a permanent solution. Duration of effect typically 6–9 months. A refresher once or twice a year is advisable.

Selected sources:

Fanian F, et al. (2023): A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study. J Dermatolog Treat, PMID 37577796
Duteil L, et al. (2023): The Effects of a Non-crossed-linked Hyaluronic Acid Gel on the Aging Signs of the Face versus Normal Saline: A Randomized, Double-blind, Placebo-controlled, Split-faced Study. J Clin Aesthet Dermatol, PMID 36909864
Palmieri A, et al. (2017): Biorevitalization: an in vitro study on gingival fibroblast. J Biol Regul Homeost Agents, PMID 29202575

This page gives a first overview. What a treatment concretely means for you — which method, which dosage, which expectation is realistic — belongs in a personal consultation at the practice. Unhurried, with findings, with time.

Treating physician

Dr. med. Thomas Ackermann

Specialist in anesthesiology · Medical director, Harmonie der Ästhetik

This procedure does not change shape — anyone expecting volume will be disappointed. In the consultation I draw a clear line between skin quality and contour, because each calls for a different approach.

Background and career →

The next step

Findings first. Then the decision.

In the initial consultation, we clarify whether the treatment makes sense for you — and what's realistic to expect. Herzogenaurach, twelve minutes by car from Erlangen.

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FAQ

Frequently asked questions about Bio-Remodelling

What's the difference between Bio-Remodelling and a classic hyaluronic acid filler?

A classic filler is injected locally as a "cushion" and adds volume. Bio-Remodelling HA distributes through the tissue as an "active ingredient" and stimulates the skin's own collagen production. Classic filler = volume, Bio-Remodelling = skin quality.

How many sessions do I need?

Standard: 2 sessions about 30 days apart. A 3rd session 30 days later if needed. Refresher typically after 6–9 months.

When will I see results?

Early hydration effects are visible within days. The actual Bio-Remodelling effect (skin quality, tone, elasticity) develops over 4–8 weeks after the 2nd session.

How long does the effect last?

Typically 6–9 months. Longer with good skincare and a healthy lifestyle. Regular refreshers improve the cumulative effect.

Where is Bio-Remodelling typically used?

Classic indications: neck, cheeks, hands, décolletage. Other areas (lips, tear trough, structural mid-face) are better treated with other materials.

Does the treatment hurt?

5 very fine injections per area. Usually well tolerated without anesthesia. Brief wheals at the injection points are normal and subside after 24–48 hours.

Is there any downtime?

Wheals at the injection sites directly after treatment — visible for 24–48 hours. After that, no visible sign of the treatment. Make-up possible the next day.

Which Bio-Remodelling product do you use?

We use an approved, stabilized hyaluronic acid product with a Bio-Remodelling effect profile from a reputable manufacturer. Brand names are not advertised on the website — we clarify all details transparently in the personal consultation.

Can Bio-Remodelling be combined with other treatments?

Yes — often advisable. A classic combination: Bio-Remodelling for skin quality as "tissue conditioning," followed by structural filler for volume restoration. In the Holistic Concept, the sequence is planned individually.

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Calcium Hydroxylapatite (CaHA)

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Hybrid Biostimulator (HA + CaHA)

Versatile combination — immediate volume plus bio-regeneration

Polynucleotides (Skin)

Bio-active variant for skin quality — very gentle, different effect class

Holistic Hyaluronic Acid Concept

Premium hub with material choice per area — Bio-Remodelling as "tissue conditioning"

Cheek Augmentation

Structural volume replacement — a complement to Bio-Remodelling treatment

After your treatment: what to keep in mind in the first hours and days is covered on the aftercare page for hyaluronic acid filler — read the guidance.

Should a hyaluronic acid result ever not be to your liking, or need correction: a hyaluronic acid treatment can be dissolved again with the enzyme hyaluronidase — on request ultrasound-guided, i.e. dissolving hyaluronic acid under direct visualization.